Arundic acid (ONO-2506) 是一种星形胶质细胞调节剂，通过抑制 S-100β 来调节星形胶质细胞的活化，从而延缓脑梗死的扩大；合成。
| Cas No. | 185517-21-9 |
| 别名 | (R)-(-)-2-丙基辛酸,ONO-2506; (R)-2-Propyloctanoic acid |
| 化学名 | (R)-2-propyloctanoic acid |
| Canonical SMILES | OC([C@H](CCC)CCCCCC)=O |
| 分子式 | C11H22O2 |
| 分子量 | 186.29 |
| 溶解度 | <18.63mg/ml in DMSO;<18.63mg/ml in ethanol |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer’s disease[1][2][3]. References:
[1]. Tomoyuki Hasegawa, et al. Process Development of ONO-2506: A Therapeutic Agent for Stroke and Alzheimer's Disease. Org. Process Res. Dev.200372168-171.
[2]. Kato H, et al. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTPneurotoxicity in mice. Brain Res. 2004 Dec 24;1030(1):66-73. |
