Tesaglitazar 是一种双重过氧化物酶体增殖物激活受体 (PPAR) α/γ 激动剂，对 PPARγ 比对 PPARα 更有效，对大鼠 PPARα 和人 PPARα 的 EC50 分别为 13.4 μM 和 3.6 μM，对大鼠均约为 0.2 μM和人类 PPARγ。
| Cas No. | 251565-85-2 |
| 别名 | (S)-2-乙氧基-3-{4-[2-(4-甲磺酰基苯基)-乙氧基-苯基]-丙酸 |
| 化学名 | (S)-2-ethoxy-3-(4-(4-((methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid |
| Canonical SMILES | OC([C@H](CC(C=C1)=CC=C1OCCC(C=C2)=CC=C2OS(=O)(C)=O)OCC)=O |
| 分子式 | C20H24O7S |
| 分子量 | 408.47 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 50 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. References:
[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74. |
