MY-5445 是环状 GMP 磷酸二酯酶 5 型磷酸二酯酶 (PDE5) 的特异性抑制剂，Ki 为 1.3 μM。
| Cas No. | 78351-75-4 |
| 别名 | 1-(3-氯苯胺基)-4-苯基酞嗪 |
| 化学名 | N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
| Canonical SMILES | ClC1=CC(NC2=NN=C(C3=CC=CC=C3)C4=C2C=CC=C4)=CC=C1 |
| 分子式 | C20H14ClN3 |
| 分子量 | 331.8 |
| 溶解度 | DMF: 2 mg/ml,DMSO: 2 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MY-5445 is a specific phosphodiesterase type 5 (PDE5) inhibitor[1]. References:
[1]. Nagendran J, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007 Jul 17;116(3):238-48. |
