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15-deoxy-Δ-12,14-Prostaglandin J2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
15-deoxy-Δ-12,14-Prostaglandin J2图片
CAS NO:87893-55-8
包装:1mg
市场价:3510元

15-deoxy-Δ-12,14-Prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素，是 PGD2 的代谢物。
Cas No.87893-55-8
别名15-deoxy-Δ12,14-PGJ2
化学名(E)-7-((S,Z)-5-((E)-oct-2-en-1-ylidene)-4-oxocyclopent-2-en-1-yl)hept-5-enoic acid
Canonical SMILESO=C1/C([C@H](C=C1)C/C=C/CCCC(O)=O)=C\C=C\CCCCC
分子式C20H28O3
分子量316.44
溶解度DMF: >100 mg/ml (from PGD2), DMSO: >20 mg/ml, Ethanol: >75 mg/ml (from PGD2)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 μM in a murine chimera system.[1],[2] 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 μM.[1]

Reference:
[1]. Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83(5), 813-819 (1995).
[2]. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83(5), 803-812 (1995).

 
 
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