Trofosfamide 是一种具有抗肿瘤活性的口服生物可利用的恶氮磷衍生物。
| Cas No. | 22089-22-1 |
| 别名 | 曲磷胺 |
| 化学名 | N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine,2-oxide |
| Canonical SMILES | ClCCN(CCCl)P1(OCCCN1CCCl)=O |
| 分子式 | C9H18Cl3N2O2P |
| 分子量 | 323.6 |
| 溶解度 | DMF: 50mg/mL,DMSO: 30mg/mL,Ethanol: 50mg/mL,PBS (pH 7.2): 10mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1]. References:
[1]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.
[2]. Gorn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9. |
