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Psicofuranine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Psicofuranine图片
CAS NO:1874-54-0
包装与价格：
包装价格(元)
1mg询价
5mg询价

Psicofuramine 是一种核苷类抗生素，对黄嘌呤 5'-磷酸氨基酶有抑制作用。
Cas No.1874-54-0
别名阿洛酮糖腺苷,Angustmycin C,NSC 53104
化学名1'-C-(hydroxymethyl)-adenosine
Canonical SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@@](N2C=NC3=C2N=CN=C3N)(CO)O1
分子式C11H15N5O5
分子量297.3
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Psicofuranine is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM [1][2][3].

Xanthosine 5’-phosphate (XMP) aminase is an enzyme essential for guanine nucleotide synthesis and possess catalytic activity with either glutamine or ammonia as a substrate [2][3].

Psicofuranine (9-n-psicofuranosy-6-aminopurine) is an antibiotic that acts as an inhibitor of xanthosine 5’-phosphate (XMP) aminase with IC50 value of 67 μM. In unfractionated preparations of both strains B-24 and B-35-2, 6.7 X 10-5M psicofuranin inhibited 50% XMP aminase after 2 minutes. Psicofuranine caused a guanine deficiency in enteric bacteria by inhibition of XMP aminase [2]. Psicofuranine-inhibited aminase couldn’t catalyze the aminolysis of the preformed intermediate to AMP and GMP, nor could it condense ATP and XMP to form the intermediate [3]. Psicofuranine had good antibacterial activity in vivo and antitumor activity [1].

References:
[1].  Ladislav J. Hanka. MECHANISM OF ACTION OF PSICOFURANINE. J Bacteriol. 1960 Jul; 80(1): 30–36.
[2].  UDAKA S, MOYED HS. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803.
[3].  Fukuyama TT. Formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. J Biol Chem. 1966 Oct 25;241(20):4745-9.

 
 
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