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Pyridoxal 5 phosphate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pyridoxal 5 phosphate图片
CAS NO:54-47-7
包装:1g
市场价:350元

5 磷酸吡哆醛是维生素 B6 的活性形式，可作为逆转录酶抑制剂，用于治疗迟发性运动障碍。
Cas No.54-47-7
别名磷酸吡哆醛; Pyridoxal 5′-phosphate; Pyridoxyl phosphate
化学名(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
Canonical SMILESCC1=C(O)C(C=O)=C(COP(O)(O)=O)C=N1
分子式C8H10NO6P
分子量247.14
溶解度≥ 12.35mg/mL in DMSO with ultrasonic and warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Pyridoxal phosphate results in an imnediate reduction in the rate of DNA synthesis[1]. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost[2].

References:
[1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7.
[2]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5.

 
 
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