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Sandramycin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sandramycin图片
CAS NO:100940-65-6
包装与价格：
包装价格(元)
1mg询价
5mg询价

山德拉霉素是一种从诺卡氏菌的培养液中分离出来的环状缩肽抗生素。
Cas No.100940-65-6
别名山卓霉素
化学名N-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-L-valine, bimol. (5→1'3),(5'→13)-dilactone
Canonical SMILESO=C([C@@H](COC([C@@H](N(C(CN(C(CNC([C@@](CCCC1)([H])N1C2=O)=O)=O)C)=O)C)C(C)C)=O)NC(C3=NC(C=CC=C4)=C4C=C3O)=O)N(CCCC5)[C@]5([H])C(NCC(N(CC(N([C@H](C(OC[C@H]2NC(C6=NC(C=CC=C7)=C7C=C6O)=O)=O)C(C)C)C)=O)C)=O)=O
分子式C60H76N12O16
分子量1221.3
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a Nocardioides sp [1].

Sandramycin is an antitumor antibiotic. Sandramycin was closely related to the cyclic depsipeptides luzopeptins A, B, C and D. Sandramycin exhibited strong inhibition to the Gram-positive organisms Bacillus subtilis, Staphylococcus aureus and Streptococcusfaecalis. Its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin A [1]. Sandramycin was also a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules [2].

In transplantable mouse leukemia P388, Sandramycin was moderately active with values comparable to those for luzopeptin A. Injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1].

References:
[1].  Matson JA, Bush JA. Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties. J Antibiot (Tokyo). 1989 Dec;42(12):1763-7.
[2].  Boger DL, Saionz KW. DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. Bioorg Med Chem. 1999 Feb;7(2):315-21.

 
 
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