Phthalimide-PEG4-MPDM-OH是一种 PROTAC linker，属于 PEG 类。Phthalimide-PEG4-MPDM-OH 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体: 一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
| 生物活性 | Phthalimide-PEG4-MPDM-OH is aPROTAClinker, which refers to thePEGscomposition. Phthalimide-PEG4-MPDM-OH can be used in the synthesis of a series ofPROTACs.PROTACscontain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACsexploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| IC50& Target[1] | |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
