Phthalimide-PEG3-C2-OTs

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

382162-12-1

Phthalimide-PEG3-C2-OTs (Compound 5) 是一种 PROTAC linker，属于 PEG 类。Phthalimide-PEG3-C2-OTs 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过 linker 连接的不同配体; 一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

生物活性

Phthalimide-PEG3-C2-OTs (Compound 5) is aPROTAClinker, which refers to thePEGscomposition. Phthalimide-PEG3-C2-OTs can be used in the synthesis of a series ofPROTACs.PROTACscontain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACsexploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

IC₅₀& Target^[1]

PEGs

分子量

477.53

Formula

C₂₃H₂₇NO₈S

CAS 号

382162-12-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.