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ANQ 11125
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ANQ 11125图片
CAS NO:153966-48-4
包装:1mg
市场价:2930元

ANQ 11125 是一种有效的选择性胃动素拮抗剂，pKd 为 8.24。
Cas No.153966-48-4
化学名(2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S)-17-((Z)-((3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S)-23-amino-11,17-dibenzyl-14-((S)-sec-butyl)-1,4,7,10,13,16,19,22-octahydroxy-5-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-20-isopropyl-24-phenyl-3,6,9,12,15
Canonical SMILESCC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](N)([H])CC1=CC=CC=C1)([H])C(C)C)([H])CC2=CC=CC=C2)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CC
分子式C86H125N19O21
分子量1761.05
溶解度Soluble in water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ANQ 11125 is a selective antagonist of motilin receptor with pKd of 8.24 [1].

Motilin receptor is a G protein-coupled receptor for motilin and stimulates contraction of gut smooth muscle.

ANQ 11125 is a selective motilin receptor antagonist. The affinity of ANQ 11125 for motilin receptor is about 10 times less than motilin [1]. In rabbit antral smooth muscle tissue, ANQ-11125 bound to motilin receptor with pKd value of 8.16. While, ANQ-11125 didn’t induce contractions of rabbit duodenum. ANQ-11125 (10-5 M) induced contractile response by 29% compared to ACh [2].

References:
[1].  Depoortere I, Macielag MJ, Galdes A, et al. Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur J Pharmacol, 1995, 286(3): 241-247.
[2].  Peeters TL, Depoortere I, Macielag MJ, et al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun, 1994, 198(2): 411-416.

 
 
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