| Cas No. | 94944-70-4 |
| 别名 | 1-[5-[(1R,2S,3R)-1,2,3,4-四羟基丁基]-1H-咪唑-2-基]乙酮 |
| Canonical SMILES | CC(=O)c1ncc([C@@H](O)[C@H](O)C(O)CO)[nH]1 |
| 分子式 | C9H14N2O5 |
| 分子量 | 230.2 |
| 溶解度 | DMSO: 2 mg/ml,PBS (pH 7.2): 0.15 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists. |
