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H2S Donor 5a
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
H2S Donor 5a图片
CAS NO:134861-13-5
包装与价格：
包装价格(元)
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H2S Donor 5a 是一种半胱氨酸激活的 H2S 供体。
Cas No.134861-13-5
别名N-(苯甲酰基硫基)苯甲酰胺,N-(Benzoylthio)benzamide
Canonical SMILESO=C(SNC(C1=CC=CC=C1)=O)C2=CC=CC=C2
分子式C14H11NO2S
分子量257.3
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

H2S (Hydrogen sulfide) Donor 5a, as a stable, cysteine activated hydrogen sulfide donor, can react with reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione to release H2S. H2S Donor 5a is very stable in aqueous solution, however, it will degrade and release H2S in biological samples containing thiols such as blood, tissues or cells.[1]

H2S exerts cytoprotective and anticancer effects, promotes wound healing, inhibits platelet aggregation and protects against myocardial ischemia, etc.[2]

In vitro experiment it shown that 0.5 mg/mL and 2 mg/mL of the most promising material (5A@Chi) was loaded with H2S and added to the HeLa cells. Both concentrations, which correspond to a H2S release of 0.49 μM and 2.20 μM, respectively, indicated no toxicity after 48 h to the cells.[3]

References:
[1]Zhao Y, et al. Cysteine-activated hydrogen sulfide (H2S) donors. J Am Chem Soc. 2011 Jan 12;133(1):15-7.
[2]Zheng Y., et al. Toward hydrogen sulfide based therapeutics: Critical drug delivery and developability issues. Med. Res. Rev. 2018;38:57–100.
[3]Batista M, et al. Chitosan Biocomposites for the Adsorption and Release of H2S. Materials (Basel). 2021 Nov 7;14(21):6701.

 
 
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