Dopamineserotoninantagonist-1是dopamine和serotonin受体拮抗剂，对多巴胺D1，D2，D4和血清素S2A，S2C，S3的Ki值分别为200，2500，420，39，84，40nM。
| Cas No. | 1977-07-7 |
| 别名 | 氯氮平杂质,Deschloroclozapine |
| Canonical SMILES | CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1 |
| 分子式 | C18H20N4 |
| 分子量 | 292.38 |
| 溶解度 | DMSO : ≥ 83.3 mg/mL (284.90 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively. [1]. Phillips ST, et al. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. J Med Chem. 1994 Aug 19;37(17):2686-96. |
