Mizoribine (NSC 289637) 抑制?HCV?RNA 复制，具有抗 HCV 活性，IC50?约为 100 μM。Mizoribine 是一种免疫抑制剂。Mizoribine 抑制?IMPDH。Mizoribine 抑制?SARS-CoV?复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50?分别为 3.5 μg/mL 和 16 μg/mL。
| Cas No. | 50924-49-7 |
| 别名 | 咪唑立宾; NSC 289637; HE 69 |
| 化学名 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide |
| Canonical SMILES | C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N |
| 分子式 | C9H13N3O6 |
| 分子量 | 259.22 |
| 溶解度 | ≥ 88.2mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mizoribine (NSC 289637; HE 69), an imidazole nucleoside, has been used as an immunosuppressive agent. Mizoribine (NSC 289637; HE 69) also is an Hsp60 inhibitor. References:
[1]. Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575-97.
[2]. Aizawa T, et al. Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: A possible benefit of its use in the treatment of lupus nephritis. Nephrology (Carlton). 2014 Jan;19(1):47-52.
[3]. Zhang M, et al. Study of the efficacy of mizoribine in lupus nephritis in Chinese patients. Rheumatol Int. 2013 Nov;33(11):2737-42. |
