SJF620 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价

SJF620 hydrochloride 是一种由Cereblon配体和Btk配体相连的PROTAC，DC₅₀为 7.9 nM。SJF620 含有 Lenalidomide 类似物，可募集 CRBN。

生物活性

SJF620 hydrochloride is aPROTACconnected by ligands forCereblonandBtkwith aDC₅₀of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN^[1].

IC₅₀& Target^[1]

Cereblon

体外研究
(In Vitro)

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC₅₀of 7.9 nM in Burkitt lymphoma cell line NAMALWA^[1].

体内研究
(In Vivo)

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t_1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802^[1].

分子量

797.30

性状

Solid

Formula

C₄₁H₄₅ClN₈O₇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)