MS33

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MS33

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2407449-11-8

MS33 是一种有效的WDR5降解剂，对VCB和WDR5的K_d值分别为 870 nM 和 120 nM。MS33 以 E3 连接酶 VHL 和蛋白酶体依赖性方式诱导 WDR5 降解。MS33 可用于急性髓系白血病的研究。

生物活性

MS33 is a potentWDR5degrader, withK_ds of 870 nM and 120 nM forVCBandWDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia^[1]^[2]^[3].

IC₅₀& Target^[1]

VHL

WDR5

120 nM (Kd)

VCB

870 nM (Kd)

体外研究
(In Vitro)

MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells^[1].

Western Blot Analysis^[1]

Cell Line:	MV4;11 cells
Concentration:	0.05, 0.1, 0.5, 1, 5 μM
Incubation Time:	1, 2, 4, 8, 16, 24 hours
Result:	Concentration- and time-dependently induced WDR5 degradation. The DC₅₀of MS33 was 260 nM, and the maximum degradation of 71%.

分子量

1208.48

Formula

C₆₄H₈₄F₃N₁₁O₇S

CAS 号

2407449-11-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.