Lewis Y tetrasaccharide (Lewis Y, Le^Y) is a tetrasaccharide derivative form ofLewis X trisaccharide(HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis^[1][2].

Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells^[1].
Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of Le^Y(RMG-1-hFUT)^[2].
Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells^[2].
Anti-Le^Yantibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo^[2].

675.63

C₂₆H₄₅NO₁₉

82993-43-9

• Saccharides
• Polysaccharides

human

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