FGFR-IN-8

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FGFR-IN-8

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2640217-64-5

FGFR-IN-8 (Compound 17a) 一种高效且具有口服活性的FGFR抑制剂，可抑制野生型和突变型 FGFR。 FGFR-IN-8 对 FGFR1、V564F-FGFR2、N549H-FGFR2、V555M-FGFR3、FGFR3 和 FGFR 4的IC₅₀值分别为<0.5、189.1、<0.5、22.6、<0.5 和 7.30 nM。FGFR-IN-8 诱导癌细胞凋亡（apoptosis），具有抗癌活性。

生物活性

FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFRinhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition withIC₅₀values of<0.5, 189.1,<0.5, 22.6,<0.5 and 7.30 nM againstFGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3,FGFR3andFGFR4, respectively. GFR-IN-8 inducescancercellapoptosisand shows anticancer activities^[1].

IC₅₀& Target

FGFR1

<0.5 nM (IC₅₀)

V564F-FGFR2

189.1 nM (IC₅₀)

N549H-FGFR2

<0.5 nM (IC₅₀)

V555M-FGFR3

22.6 nM (IC₅₀)

FGFR3

<0.5 nM (IC₅₀)

FGFR4

7.30 nM (IC₅₀)

V561M-FGFR1

262.5 nM (IC₅₀)

K650E-FGFR3

<0.5 nM (IC₅₀)

K650M-FGFR3

4.8 nM (IC₅₀)

分子量

584.50

Formula

C₂₇H₃₁Cl₂N₉O₂

CAS 号

2640217-64-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.