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HNMPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HNMPA图片
CAS NO:132541-52-7

HNMPA 是一种膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 抑制人胰岛素受体的丝氨酸和酪氨酸自磷酸化。HNMPA 对蛋白激酶 C 或环 AMP 依赖性蛋白激酶活性没有影响。
生物活性

HNMPA is a membrane impermeableinsulin receptortyrosine kinaseinhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the humaninsulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

体外研究
(In Vitro)

HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1].
HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].

分子量

238.18

Formula

C11H11O4P

CAS 号

132541-52-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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