| CAS NO: | 91032-26-7 |
glycopeptide antibiotic
| Cas No. | 91032-26-7 |
| 别名 | 替考拉宁A2-2 |
| 化学名 | 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone |
| Canonical SMILES | O[C@@H]([C@H](O)[C@@H](CO)O1)[C@H](O)[C@H]1OC2=CC(O)=CC([C@@H](C(O)=O)NC([C@@]([C@@H](C3=CC(Cl)=C(OC4=CC5=CC(OC6=CC=C7C=C6Cl)=C4O[C@H]8[C@H](NC(CCCCCCC(C)C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C=C3)O[C@]9([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9NC(C)=O)([H] |
| 分子式 | C88H97Cl2N9O33 |
| 分子量 | 1879.7 |
| 溶解度 | ≤10mg/ml in DMSO;1mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Teicoplanin A2-2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. Teicoplanin consists of five major components (A2-1 through A2-5), one hydrolysis component (A3-1), and four minor components (RS-1 through RS-4) [1]. Teicoplanin is isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria [2]. In vitro: Teicoplanin inhibited cell wall synthesis in Bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of UDP-N-acetyl-muramyl-pentapeptide. In a cell-free system from Bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis [2]. In vivo: Following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. Animal data showed high concentrations in most tissues, and particularly high in liver and kidneys [3]. References: [1] Bernareggi A, Borghi A, Borgonovi M, et al. Teicoplanin metabolism in humans[J]. Antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749. [2] S. Somma, L. Gastaldo and A. Corti. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy 26(6), 917-923 (1984). [3] Rowland M. Clinical pharmacokinetics of teicoplanin[J]. Clinical pharmacokinetics, 1990, 18(3): 184-209 . |
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