首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Nisin A
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Nisin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Nisin A图片
CAS NO:1414-45-5
包装与价格：
包装价格(元)
1g询价
5g询价
10g询价

Nisin A 是由一组属于乳球菌和链球菌属的革兰氏阳性细菌产生的细菌素。
Cas No.1414-45-5
别名乳酸链球菌素,Ambicin N|Nisaplin?
化学名L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L- isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3- mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L- methionyl
Canonical SMILESO=C(N1[C@@]([H])(CCC1)C(NC2)=O)[C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C(N3)=C)=O)=O)CSC[C@@H](NC(/C(NC([C@H]([C@H](CC)C)N)=O)=C/C)=O)C(N[C@]([H])(C3=O)[C@H](CC)C)=O)=O)[C@H](C)SC[C@@H](C(N[C@H](C(N[C@@H]([C@H](C)SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C
分子式C143H230N42O37S7
分子量3354.1
溶解度≤0.25mg/ml in DMSO
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nisin A is an antibacterial peptide.

Nisin A is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics.

In vitro: Previous study showed that the sperm motility could be completely inhibited with nisin A. The minimum effective concentration of nisin A required to immobilize sperm in vitro within 20 s was found to be 50 microg in rat, 200 microg in rabbit and 300-400 microg in monkey and human. Such inhibitory effect on sperm motility was found to be dose- and time-dependent [1].

In vivo: Intravaginal administration of nisin A before mating during proestrus-estrous transition phase caused complete arrest of sperm motility and blockage of conception. Subacute toxicity studies in rats showed that, repetitive intravaginal application of nisin A at the dose of 200 microg for 14 days caused no abnormalities either in the length of estrous cycle or in the morphology of vaginal epithelial cells. Moreover, no histopathological abnormalities in vaginal tissue or any change in blood and serum biochemical profiles were seen. In addition, no adverse effects were found on subsequent reproductive performance, development of pups and neonate survival [1].

Clinical trial: Up to now, nisin A is still in the preclinical development stage.

Reference:
[1] Aranha C, Gupta S, Reddy KV.  Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo studies. Contraception. 2004 Apr;69(4):333-8.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024