AG 370

立即咨询

AG 370

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

134036-53-6

AG 370 是一种吲哚 tyrphostin，是一种有效的PDGF诱导的有丝分裂抑制剂 (IC₅₀为 20 μM)。AG 370 对 EGF 受体的抑制作用较弱。

生物活性

AG 370, an indole tyrphostin, is a potentPDGF-induced mitogenesis inhibotor (IC₅₀of 20 μM). AG 370 displays weak inhibition of theEGFreceptor^[1].

IC₅₀& Target^[1]

PDGFR

20 μM (IC₅₀)

体外研究
(In Vitro)

AG 370 blocks mitogenesis induced by epidermal growth factor (IC₅₀of 50 μM) and human serum (IC₅₀of 50 μM)^[1]^[1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor^[1]^[1].

分子量

259.27

Formula

C₁₅H₉N₅

CAS 号

134036-53-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.