HSP70-IN-3

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HSP70-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的IC₅₀分别为1.1和1.9 μM)。HSP70-IN-3 具有抗Hedgehog信号转导通路活性和抗增殖活性，并降低致癌转录因子 GLI1 的表达。

生物活性

HSP70-IN-3 is a potentHSP70inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehogsignaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1^[1].

IC₅₀& Target

IC₅₀: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2^[1]

体外研究
(In Vitro)

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells^[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation^[1].

Cell Proliferation Assay

Cell Line:	ASZ001 cells^[1]
Concentration:	5 μM
Incubation Time:	72 hours
Result:	Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line:	ASZ001 cells^[1]
Concentration:	10 μM
Incubation Time:	48 hours
Result:	After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.

分子量

883.23

Formula

C₄₈H₇₈N₆O₇S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.