| CAS NO: | 41941-56-4 |
| 生物活性 | 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependentPKAactivity. 8-Chloro-cAMP has anticancer activity[1]. | |||||||||
| 体外研究 (In Vitro) | 8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1]. | |||||||||
| 体内研究 (In Vivo) | In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1]. | |||||||||
| 分子量 | 363.65 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C10H11ClN5O6P | |||||||||
| CAS 号 | 41941-56-4 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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