LEQ506 is a second-generation inhibitor ofsmoothened(Smo) withIC₅₀s of 2 and 4 nM in human and mouse, respectively.

IC50: 2 nM (human smo), 4 nM (mouse smo)^[1]

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC₅₀~6-fold lower than that of Compound 2^[1]. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1^[2].

432.56

Solid

C₂₅H₃₂N₆O

1204975-42-7

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 100 mg/mL(231.18 mM)

*"≥" means soluble, but saturation unknown.

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