Sulprostone

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Sulprostone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60325-46-4

硫前列酮
SHB 286
CP-34089
ZK-57671

Sulprostone (SHB 286) 是一种有效的，选择性的EP3受体激动剂。Sulprostone (SHB 286) 是一种前列腺素 E2 (PGE2) 类似物，具有抗溃疡和非甾体类抗流产作用。Sulprostone 有潜力用于终止妊娠和分娩时的出血。

生物活性

Sulprostone (SHB 286) is a potent and selectiveEP3 receptoragonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery^[1]^[2]^[3].

IC₅₀& Target^[1]^[2]

体外研究
(In Vitro)

Sulprostone (SHB 286) has K_ivalues of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells^[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs^[2].

体内研究
(In Vivo)

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T_1/2of 0.451 hours, a CL of 56 mL/minokg, a V_ssof 0.583 L/kg and an AUC of 149 ngoh/mL^[3].

Animal Model:	Male cynomolgus monkey^[3]
Dosage:	0.5 mg/kg (Pharmacokinetic Analysis)
Administration:	IV
Result:	Had a T_1/2of 0.451 hours, a CL of 56 mL/minokg, a V_ssof 0.583 L/kg and an AUC of 149 ngoh/mL.

Clinical Trial

分子量

465.56

性状

Liquid

Formula

C₂₃H₃₁NO₇S

CAS 号

60325-46-4

中文名称

硫前列酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years