MU1700

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MU1700

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MU1700 是一种具有口服活性的、强效的ALK1/2抑制剂，IC₅₀分别为 13 nM 和 6 nM，其具有细胞膜通透性以及高脑渗透性。

生物活性

MU1700 is an orally active and potentALK1/2inhibitor withIC₅₀s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability^[1].

IC₅₀& Target^[1]

ALK2

6 nM (IC₅₀)

ALK1

13 nM (IC₅₀)

ALK6

41 nM (IC₅₀)

体外研究
(In Vitro)

MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 μM in U2OS cells^[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	U2OS cells
Concentration:	0.1-50 μM
Incubation Time:	24 h
Result:	Showed cytotoxic effect above 2.5 μM concentration significantly.

体内研究
(In Vivo)

1.19Pharmacokinetic (PK) Profile in Mice (P.O., 20 mg/kg)^[1]

Dose	20 mg/kg
Bioavailability	79 %
Cl (ml/min/kg)	30 (IV)
T_1/2	2.5 h
C_max(PO)	3697 nM
C_brain/C_plasma(4h, 100 mg/kg)	25

分子量

406.48

Formula

C₂₆H₂₂N₄O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.