TGFBR1-IN-1 is anALK5inhibitor extracted from patent WO2018004290A1, Compound 33, has anIC₅₀of 10-100 nM^[1].

Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease^[1].

427.48

C₂₃H₁₇N₅O₂S

2170830-26-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.