TEI-9648, a Vitamin D₃Lactone analogue, is a potent and specificvitamin D receptor (VDR)antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research^[1][2].

TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)₂D₃^[1].
TEI-9648 has consistently weaker suppressive effect than TEI-9647^[1].
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell^[1].
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)₂D₃(0.1 nM) in HL-60 cells^[1].

426.59

Solid

C₂₇H₃₈O₄

173388-21-1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)