VDR agonist 1 (compound 28) 是一种非甾体类维生素 D 受体 (VDR)的激动剂， 在MCF-7 细胞中测得其IC50值为 690 nM。VDR agonist 1 通过上调 p21 和 p27 的表达来抑制细胞周期，通过增加 BAX 的表达来促进细胞凋亡，降低 Bcl-2 的表达。
| 生物活性 | VDR agonist 1 (compound 28) is a nonsteroidalVitamin D receptor (VDR)agonist, with anIC50of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotesapoptosisby increasing the expression ofBAXand decrease the expression ofBcl-2[1]. |
| IC50& Target | IC50: 690 nM (VDR in MCF-7 cells)[1]. |
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
