S-23

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S-23

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1010396-29-8

S-23 是一种口服选择性雄激素受体调节剂(SARM)，K_i为 1.7 nM。S-23 诱导 CV-1 细胞雄激素受体介导的转录激活。S-23 增加去势大鼠前列腺、精囊和肛提肌重量。

生物活性

S-23 is an orally active selectiveandrogen receptormodulator (SARM) with aK_iof 1.7 nM. S-23 inducesandrogen receptor(AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats^[1]^[2].

IC₅₀& Target

Ki: 1.7 nM (Androgen receptor)^[1]

体外研究
(In Vitro)

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM^[1].

体内研究
(In Vivo)

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED₅₀of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively^[1].

Animal Model:	Male Sprague Dawley rats (in castrated male rats)^[1]
Dosage:	0.01-3 mg
Administration:	S.c.; daily for 14 d
Result:	Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.

分子量

416.75

性状

Solid

Formula

C₁₈H₁₃ClF₄N₂O₃

CAS 号

1010396-29-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(239.95 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3995 mL	11.9976 mL	23.9952 mL
5 mM	0.4799 mL	2.3995 mL	4.7990 mL
10 mM	0.2400 mL	1.1998 mL	2.3995 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。