CAS NO: | 1481401-71-1 |
生物活性 | FLTX1 is a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-permeabilized conditions. FLTX1 exhibits the potent antiestrogenic properties of Tamoxifen in breastcancercells. FLTX1 is devoid of the estrogenic agonistic effect on the uterus[1][2]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | FLTX1 (0.01-10 μM; 6 d) reduces MCF7 cell proliferation in a dose-dependent manner. FLTX1 (pretreated 24 h) counteracts the increase in cell growth induced by E2down to the vehicle level[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | FLTX1 (0.01-1 mg/kg/d; s.c. for 3 d) is lacked of the estrogenic uterotrophic (and also cervical and vaginal), hyperplasic and hypertrophic effects, and failed to alter basal proliferating cell nuclear antigen immunoreactivity in mice and rats[1]. | ||||||||||||||||
分子量 | 520.58 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C31H28N4O4 | ||||||||||||||||
CAS 号 | 1481401-71-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(48.02 mM;Need ultrasonic) 配制储备液
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