2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM.
| Cas No. | 15397-12-3 |
| 别名 | 2'-C-甲基腺苷 |
| Canonical SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@@](O)(C)[C@H](O)[C@@H](CO)O3 |
| 分子式 | C11H15N5O4 |
| 分子量 | 281.3 |
| 溶解度 | DMF: 5 mg/mL,DMSO: 20 mg/mL,PBS (pH 7.2): 10 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM. It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 µM) and eradicates it when used at a concentration of 10 µM. |
