Ciwujianoside C3 是一种具有口服活性并可以穿透血脑屏障的化合物，分离于刺五加的叶子。 Ciwujianoside C3 具有抗炎作用，并可以增强小鼠个体的识别记忆力。
| 生物活性 | Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory[1][2]. |
体外研究
(In Vitro) | Cell Viability Assay[1] | Cell Line: | RAW 264.7 cells | | Concentration: | 10 μM, 20 μM and 40 μM | | Incubation Time: | 24 hours | | Result: | Has no effect on cell cytotoxicity and inhibits NO production |
Western Blot Analysis[1] | Cell Line: | RAW 264.7 cells | | Concentration: | 10 μM, 20 μM and 40 μM | | Incubation Time: | 24 hours | | Result: | Decreases p-ERK and p-JNK expression. |
RT-PCR[1] | Cell Line: | RAW 264.7 cells | | Concentration: | 10 μM, 20 μM and 40 μM | | Incubation Time: | 24 hours | | Result: | Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner. |
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体内研究
(In Vivo) | | Animal Model: | Mice[1] | | Dosage: | 0.5 mg/kg | | Administration: | Oral administration; 0.5 mg/kg/day; 17 days | | Result: | Reinforced object recognition memory. |
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| 来源 | - Plants
- Araliaceae
- Acanthopanax henryi(Oliv.) Harms
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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