AKR1C3-IN-5 (Compound 6e) 是一种有效的AKR1C3抑制剂。AKR1C3 酶在激素依赖性前列腺和乳腺肿瘤中过度表达。 AKR1C3-IN-5 源自 drupanin，其对 MCF-7 细胞的半数抑制浓度 (IC50) 为 9.6 ± 3 μM，选择性指数 (SI) 为 5.5。
| 生物活性 | AKR1C3-IN-5 (Compound 6e) is a potent inhibitor ofAKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
