Chst15-IN-1

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Chst15-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2158198-77-5

Chst15-IN-1 是一种有效的可逆共价Chst15抑制剂。Chst15-IN-1 有效抑制 chondroitin sulfate-E (CS-E) 硫酸盐化水平和其他密切相关的glycosaminoglycans (GAG) sulfotransferases。Chst15-IN-1 作为一种选择性sulfotransferase抑制剂可以降低 chondroitin sulfate proteoglycans (CSPGs) 的抑制作用，并有希望用于刺激神经元修复。

生物活性

Chst15-IN-1 is a potent reversible covalentChst15inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely relatedglycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selectivesulfotransferaseinhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair^[1].

IC₅₀& Target

Chst15^[1]

体外研究
(In Vitro)

Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression^[1].

体内研究
(In Vivo)

Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours^[1].

Animal Model:	Rats
Dosage:	3.0 mg/kg (Pharmacokinetic Analysis)
Administration:	I.v.
Result:	Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.

分子量

442.09

性状

Solid

Formula

C₁₇H₁₁BrCl₂N₂O₃

CAS 号

2158198-77-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL(113.10 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2620 mL	11.3099 mL	22.6198 mL
5 mM	0.4524 mL	2.2620 mL	4.5240 mL
10 mM	0.2262 mL	1.1310 mL	2.2620 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。