Liothyronine sodium hydrate

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CAS NO:

345957-19-9

三碘代甲状腺素钠盐水合物
Triiodothyronine sodium hydrate
3,3',5-Triiodo-L-thyronine sodium hydrate
T3 sodium hydrate

Liothyronine sodium hydrate 是一种有效的甲状腺激素。Liothyronine sodium hydrate 是有效的TRα和TRβ激动剂，对 hTRα 和 hTRβ 的K_i值均为 2.33 nM。

生物活性

Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptorsTRαandTRβagonist withK_is of 2.33 nM for hTRα and hTRβ, respectively^[1]^[2]^[3].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Liothyronine (T3, 100 nM) sodium hydrate stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed^[1]. Liothyronine sodium hydrate binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine sodium hydrate promotes growth, induces differentiation and regualtes metabolic effects^[2].

Clinical Trial

Formula

C₁₅H₁₂I₃NO₄.xH₂O.Na

CAS 号

345957-19-9

中文名称

三碘代甲状腺素钠盐水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.