MRL-871 (compound 3) 是一种有效的变构的维甲酸受体相关孤儿受体 γt (RORγt) 反向激动剂，IC50为 264 nM。MRL-871 具有独特的异恶唑化学型，可有效减少 EL4 细胞中 IL-17a mRNA 的生成。
| 生物活性 | MRL-871 (compound 3) is a potent and allostericretinoic acid receptor-related orphan receptor γt (RORγt)inverse agonists with anIC50of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reducesIL-17amRNA production in EL4 cells[1]. |
体外研究
(In Vitro) | MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
