(±)-ML 209

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(±)-ML 209

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CAS NO:

1334526-14-5

(±)-ML 209 (compound 4n) 是一种二苯基丙酰胺，一种视黄酸相关的孤儿受体RORγ拮抗剂，IC₅₀为 1.1 μM。(±)-ML 209 在 HEK293t 细胞中抑制 RORγt 转录活性，IC₅₀为 300 nM。(±)-ML 209 抑制细胞中 RORγt 的转录活性，但不抑制 RORα。(±)-ML 209 选择性抑制鼠 Th17 细胞分化，而不影响幼稚 CD4⁺T 细胞分化为 Th1 和调节性 T 细胞。

生物活性

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptorRORγantagonist with anIC₅₀of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC₅₀of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but notRORαin cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naiveCD4⁺T cells into other lineages, including Th1 and regulatory T cells^[1].

IC₅₀& Target^[1]

RORγ

1.1 μM (IC₅₀)

分子量

441.52

Formula

C₂₅H₃₁NO₆

CAS 号

1334526-14-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.