Pedaliin 是从芝麻 (Sesamum indicum L) 叶 (SLs) 的乙醇提取物中提取的一种生物活性成分。Pedaliin 具有体外抗氧化和抗结肠癌作用，具有自由基清除活性和铁还原抗氧化能力 (FRAP)。
| 生物活性 | Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-coloncancerefficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP)[1][2]. |
体外研究
(In Vitro) | Pedaliin (0-35 μM; 72 h) dose-dependently attenuates the growth of human colon cancer cells, HT29 and HCT116[1].
Pedaliin (3.5-35 μM; 30 min; 37 ℃) has ferric reducing antioxidant power (FRAP)[1].
Pedaliin (7 μM; 48 h) alleviates invasion and migration of HT29 and HCT116 cells in non-cytotoxic conditions[1].
Pedaliin (20 μL) shows high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and in vitro antiglycation activities, and inhibits BSA glycation with an IC50value of 41.8 μM[2].
Cell Viability Assay[1] | Cell Line: | HCT116 cells | | Concentration: | 0, 3.5, 7, 17.5, and 35 μM | | Incubation Time: | 48 hours or 72 hours | | Result: | Inhibited cell growth (72 h) by 24% at 3.5-35 μM, invasion (48 h) by 18% at 7 μM, and migration (48 h) by 33% at 7 μM. |
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| 来源 | - Plants
- Pedaliaceae
- Sesamum indicumLinn.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
