Malvidin-3-O-arabinoside chloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

28500-04-1

Malvidin-3-O-arabinoside chloride 通过刺激 Ampk 介导的自噬(autophagy)，改善氨基甲酸乙酯诱导的氧化损伤。

生物活性

Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediatedautophagy^[1].

体外研究
(In Vitro)

Malvidin-3-O-arabinoside chloride (M3A chloride, 50-400 μM) pretreatment remarkably upregulates LAMP-1 expression, which indicates elevated lysosomal mass. M3A also successfully restores lysosomal acidity and subsequently strengthenes lysosomal functions. M3A stimulates phosphorylation of AMP-activated protein kinase (AMPK), a master regulator of autophagy^[1].

Cell Autophagy Assay^[1]

Cell Line:	Caco-2 cell line.
Concentration:	50, 100, 200 and 400 μM.
Incubation Time:	24 h (then treated with or without 10 μM chloroquine (CQ) for another 1 h).
Result:	Notably inhibited excess ROS generation. 200 μM and 400 μM M3A pretreatment significantly enhanced 14% and 16% of GSH level. Enhanced autophagy flux. Significantly up-regulate the LC3-II/LC3-I ratio.

分子量

498.86

Formula

C₂₂H₂₃ClO₁₁

CAS 号

28500-04-1

结构分类

Flavonoids
Anthocyans

Phenols
Polyphenols

来源

Plants
Ericaceae
Vaccinium myrtillusLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.