Euxanthone 是一种氧杂蒽酮衍生物，可通过触发自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 具有抗肿瘤和神经保护活性。
| 生物活性 | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress andapoptosisby triggeringautophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
体外研究
(In Vitro) | Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。
Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。
Cell Migration Assay[1] | Cell Line: | Osteosarcoma (OS) cells | | Concentration: | 10 μM, 20 μM | | Incubation Time: | 24 h | | Result: | Inhibited cell migration at 24 hr. |
Western Blot Analysis[1] | Cell Line: | Osteosarcoma (OS) cells | | Concentration: | 10 μM, 20 μM | | Incubation Time: | 24 h | | Result: | Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion. |
|
体内研究
(In Vivo) | 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。
Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。
| Animal Model: | Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] | | Dosage: | 30 mg/kg, 60 mg/kg | | Administration: | p.o.;once a day; for 7 days | | Result: | Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 中文名称 | |
| 结构分类 | - Flavonoids
- Other Flavonoids
|
| 来源 | - Plants
- Guttiferae
- Garcinia oblongifoliaChamp. ex Benth.
|
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
