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Pranoprofen(Pyranoprofen)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pranoprofen(Pyranoprofen)图片
CAS NO:52549-17-4
规格:≥98%
包装与价格:
包装价格(元)
100mg询价
250mg询价
500mg询价
1g询价
2g询价
5g询价
10g询价

理化性质和储存条件
Molecular Weight (MW)255.27
FormulaC15H13NO3
CAS No.52549-17-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 51 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (23.5 mM)
Other info

InChi Key: TVQZAMVBTVNYLA-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)

SMILES Code: CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O

SynonymsPyranoprofen; 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid
实验参考方法
In Vitro

In vitro activity: Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. Pranoprofen alone induces eIF2alpha phosphorylation, which is further increased by ER stress. Pranoprofen inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells. Pranoprofen (0.0625 to 1.0 g/L) has poignant cytotoxicity to human corneal endothelial (HCE) cells, and the extent of its cytotoxicity is dose- and time-dependent. Pranoprofen induces plasma membrane permeability elevation, DNA fragmentation, and apoptotic body formation, proving its apoptosis inducing effect on HCE cells. Pranoprofen above 0.0625 g/L has poignant cytotoxicity on HCE cells in vitro by inducing cell apoptosis, and should be carefully employed in eye clinic.

In VivoPranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively. Pranoprofen is excreted in the urine exclusively in the form of pranoprofen glucuronide in rabbit. Pranoprofen, especially the R(-)-isomer, is significantly distributed in the kidney of rabbit. Pranoprofen has a preference for glucosidation rather than glucuronidation in mice at low doses in spite of having a higher capacity of glucuronidation.
Animal modelMice, rats, guinea pigs, rabbits
Formulation & DosageN/A
References

Neurochem Int. 2009 Jan;54(1):1-6; J Pharmacobiodyn. 1990 Dec;13(12):739-44.

 
 
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