| CAS NO: | 270076-60-3 |
| 生物活性 | Pristinamycin, produced byStreptomyces pristinaespiralis, is an orally active streptogramin-likeantibioticconsisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistantStaphylococcus aureus(MRSA), Vancomycin-resistantS. aureus(VRSA) andEnterococcus faecium(VREF)[1]. | |||||||||
| 体外研究 (In Vitro) | In-vitro studies show pristinamycin to inhibitStaphylococciandStreptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2]. | |||||||||
| 体内研究 (In Vivo) | To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3]. | |||||||||
| Clinical Trial | ||||||||||
| 分子量 | 1392.55 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C73H89N11O17 | |||||||||
| CAS 号 | 270076-60-3 | |||||||||
| 结构分类 |
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| 来源 | streptogramin | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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