Garivulimab (BGB-A333) is a humanized IgG1-variant monoclonal antibody that specifically targets and binds toPD-L1. Garivulimab selectively blocks the interaction ofPD-L1andPD-1. Garivulimab has antitumor activity^[1].

Garivulimab (BGB-A333) specifically targets and binds to PD-L1, blocking interaction to its receptor, PD-1 on T cell, reversing T cell inactivation, and increases T cell expansion resulting in cytotoxic T cell-mediated antitumor immune response against PD-L1-expressing tumor cells. Garivulimab also inhibits PD-L1-induced apoptosis of activated CD8+ T cells and increases T cell proliferation^[1].

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