Basiliximab

立即咨询

Basiliximab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

179045-86-4

CHI 621

Basiliximab (CHI 621) 是一种重组嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 抗体。Basiliximab 可用于肾移植研究。

生物活性

Basiliximab (CHI 621) is a recombinant chimeric murine/humanIgG1monoclonal anti-interleukin-2 receptorantibody. Basiliximab can be used for the research of renal transplantation^[1].

IC₅₀& Target

Interleukin-2 receptor^[1]

体外研究
(In Vitro)

Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα^[1].
Basiliximab binds only to activated lymphocytes and macrophages/monocytes^[3].
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα^[3].

体内研究
(In Vivo)

Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats^[2].

Animal Model:	Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia^[2]
Dosage:	0.07 mg/rat
Administration:	IV infusion, once
Result:	Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight.

Clinical Trial

性状

Liquid

CAS 号

179045-86-4

中文名称

巴利昔单抗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.