Cbl-b-IN-3

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Cbl-b-IN-3

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CAS NO:

2573775-59-2

Cbl-b-IN-3 (Compound 23) 是 casitas B 系淋巴瘤原癌基因-b (Cbl-b) 抑制剂，IC₅₀为< 1 nM。 Cbl-b 是一种 E3 泛素连接酶，负调控 T 细胞活化。

生物活性	Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with anIC₅₀of< 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation^[1].
IC₅₀& Target	IC₅₀:< 1 nM (Cbl-b)^[1]
体外研究 (In Vitro)	Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody^[1].
分子量	537.62
Formula	C₃₀H₃₄F₃N₅O
CAS 号	2573775-59-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.