Forigerimod

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Forigerimod

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

497156-60-2

IPP-201101

Forigerimod (IPP-201101) 是一种 CD4 T 细胞调节剂。Forigerimod 是 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段，在 Ser140 位点被磷酸化。Forigerimod 可以有效抑制自噬。Forigerimod 可用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。

生物活性

Forigerimod (IPP-201101) is aCD4T-cellmodulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibitautophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE)^[1]^[2]^[3]^[4].

体内研究
(In Vivo)

Forigerimod (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬，使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷^[4]。

Animal Model:	MRL/lpr mice^[4]
Dosage:	100 μg in 100 μL saline per mouse
Administration:	Intravenous administration, single
Result:	Corrected the cell content and distribution in MRL/lpr salivary glands. Corrected the defective of autophagy processes in SGs of MRL/lpr mice.

Clinical Trial

分子量

2638.94

Formula

C₁₁₇H₁₈₁N₃₄O₃₂PS

CAS 号

497156-60-2

Sequence

Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-{Ser-phosphono}-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr

Sequence Shortening

RIHMVYSKR-{Ser-phosphono}-GKPRGYAFIEY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.