PD-1/PD-L1-IN-27

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PD-1/PD-L1-IN-27

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PD-1/PD-L1-IN-27 是一种有效的PD-1/PD-L1抑制剂，IC₅₀值为 134 nM。 PD-1/PD-L1-IN-27 具有低 T 细胞毒性的抗肿瘤作用。PD-1/PD-L1-IN-27 具有激活 CD8⁺T 细胞和减少 T 细胞耗竭的能力。

生物活性

PD-1/PD-L1-IN-27 is a potentPD-1/PD-L1inhibitor with anIC₅₀value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8⁺T cells and reduces T cell exhaustion^[1].

IC₅₀& Target

IC₅₀: 134 nM (PD-1/PD-L1)^[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN-27 (compound MZ58) (2.5, 5, 10, 50 μM; 48 h) shows antitumor effects with low T cell cytotoxicity^[1].

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	2.5, 5, 10, 50 μM
Incubation Time:	48 h
Result:	Facilitated cell proliferation with low T cell cytotoxicity.

体内研究
(In Vivo)

PD-1/PD-L1-IN-27 (10, 25 mg/kg; i.g.) shows antitumor effecct^[1].

Animal Model:	20-22 g, 6-8 weeks, male C57BL/6J mice (MC 38 cell lines)^[1]
Dosage:	10, 25 mg/kg
Administration:	I.g.
Result:	Showed antitumor effecct.

分子量

673.75

Formula

C₄₄H₃₅NO₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.